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Figure 1. Meta-analysis of placebo compared with newer antidepressants for major depression in adults.N indicates number of participants; n indicates number of studies. GABA = {gamma}-aminobutyric acid; HT = hydroxy-tryptophan; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor.