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Figure 2. Serial changes of serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) during propylthiouracil therapy in patients with hyperthyroidism. Lines with open circles indicate 15 patients with abnormal ALT levels at 2 months; closed circles indicate patients without increased ALT. Data are expressed as mean ± SE. The shaded areas represent the normal ranges of serum ALT (< 36 U/L [< 0.60 µkat/L]) and ALP (28 to 94 U/L [0.47 to 1.57 µkat/L]). The overall time comparison of mean ALT levels is significant (P < 0.01 by repeated measures analysis). When the mean ALT levels at different time points are compared, that at month 2 is statistically greater than those at months 1, 3, 4, and 5, and the level at month 3 is also statistically greater than that at month 5 but not than that at month 4 (P < 0.01 by repeated measures analysis).